compared the Pro-Argin formulation with a calcium sodium phosphosilicate toothpaste, demonstrating 88% versus 50% occlusion respectively. J Dent. 1). It is clinically proven for instant and lasting Sensitivity relief* How does it work? Colgate Sensitive PRO-Relief Provides clinically proven, everyday protection from painful sensitivity. Hines D, Rinaudi L, Xu S, Lavender S, Pilch S: The Use of Confocal Laser Scanning Microscopy and a Novel Imaging Program for Quantifying Dentine Tubule Occlusion. How does Colgate Sensitive Pro-Relief Repair & Prevent work? This clinical trial has not included a run-in or washout period before the test phase due to time constraints and compliance of the potential participants. Am J Dent. After six weeks, FCPS-based dentifrices showed greater clinical efficacy with mean scores (1.801.73) than other treatment arms for waterjet stimulated DH. A systematic review. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. Table 4 demonstrates a comparison between treatment groups observing better clinical efficacy in managing DH on SCASS. Plus it has the freshness you trust from Colgate! BMC Oral Health Hu ML, Zheng G, Lin H, Yang M, Zhang YD, Han JM. Dentine tubule occlusion by novel bioactive glass-based toothpastes. Participantswere strictly advised to refrain from acidic food and drink intake at least four hours before following up visit. Clinical efficacy of BioMin F, Colgate sensitive pro-relief and Sensodyne rapid action dentifrices in DH [Internet]. All authors read and approved the final manuscript. Besides, these findings of the current study could be related to previously conducted clinical trials indicating the better clinical effectiveness of Pro-argin than strontium acetate against air-blast and tactile stimulus after three days and one week of application [30, 31]. Part of Identifier NCT 04249336. Kp nu. J Dent Res. Madurai: Best Dental Science College; 2020. Gently and effectively removes stains. Instant relief when applied directly to the sensitive tooth with the fingertip and gently massaged for 1 minute. With regular use, the Pro-Argin formula builds a long-lasting protective barrier that acts like a seal against sensitivity. Venkataramana S, Jeyaraman SK, Kothimbakkam SSK, Chellathurai BNK. The probable reason for variations between this clinical trial and previously conducted studies could be attributed to racial or ethnic differences between the conducted trials. Directions Schulz KF, Altman DG, Moher D. CONSORT 2010 Statement: updated guidelines for reporting parallel group randomised trials. Dentin hypersensitivity treatments work in one of two ways. Colgate Sensitive Pro Relief Instant Relief, Plugging the channels that lead to sensitive tooth nerves to help relieve sensitivity. 2018. Helps protect teeth against cavities and promotes healthy gums (with regular brushing). IADR, The Excel, United Kingdom. West N, Newcombe RG, Hughes N, Mason S, Maggio B, Sufi F, et al. In addition, the frequency of participants diagnosed with DH using air blast stimulus was observed as 36.8% at the time of enrolment in the six-week clinical trial that was found consistent with findings of a survey report demonstrating 36.4% frequency of DH among adults in Karachi, Pakistan [24]. If symptoms persist, talk to your healthcare professional. Colgate Sensitive Pro-Relief works by plugging the channels to block tooth sensitivity and with regular use, it builds a long-lasting protective barrier that acts like a seal against sensitivity. found the clinical efficacy of Pro-argin better than strontium acetate for mechanical and air-blast stimulated DH on VAS and SCASS in follow-up periods of one minute, three days, two, four and eight weeks in a systematic review in 2015. In addition, they should be reproducible and clinically relevant to stimuli triggering pain in DH [35]. Comparative efficacy of BioMin-F, Colgate Sensitive Pro-relief and Sensodyne Rapid Action in relieving dentin hypersensitivity: a randomized controlled trial, https://doi.org/10.1186/s12903-021-01864-x, https://clinicaltrials.gov/ct2/show/NCT04249336, http://creativecommons.org/licenses/by/4.0/, http://creativecommons.org/publicdomain/zero/1.0/. These ingredients resulted in rapid fluorapatite crystallisation at exposed tubular ends of dentin [12]. Find products and services. Blocks the pain of sensitive teeth. J Oral Rehabil. Colgate Sensitive Pro-Relief toothpaste is a revolutionary and one-of-its kind remedy that can provide consumers suffering from Sensitivity the much needed instant and long lasting relief . However, there is a substantial possibility that these fluoridated dentifrices can reduce DH. Free postage. Thus, 128 participants completed the trial and were statistically analyzed for primary outcome measure of SCASS scores after lost to follow up (Fig. A meta-analysis by Yang et al. Colgate Sensitive Pro-Relief Instant Relief Sensitive Toothpaste - 75ml More Images Colgate Sensitive Pro-Relief Instant Relief works as a shield that blocks pathways to pain instantly. Treatment difference between FCPS, Pro-argin, and 8% strontium acetate was not statistically significant with a p>0.05 for sustained pain relief in DH. Internal report 2018, 5. Colgate SENSITIVE INSTANT Relief Repair & Prevent Toothpaste is an everyday toothpaste. For lsting relief, apply to a gentle toothbrush making sure to brush all sensitive areas of the teeth twice daily. PubMed Central Gentle whitening formula. Article The strength of this study was that participants were randomised into four treatment groups to generalise the results for the population [32]. A meta-analysis by Grnberg et al. Therefore, this trial was planned to investigate the clinical efficacy of Pro-argin and strontium acetate for immediate pain relief in DH after one minute of topical application to fill the research gap associated with limited published evidence and risk of bias in selection, performance, attrition, and reporting as predicted by Pessoa et al. J Clin Dent 2009; 20 (Spec Iss): 123-130. They don't. In our study, Pro-argin treatment revealed an immediate clinical reduction of 45.7% on SCASS, 56% on VAS used for mechanical stimuli, and 48.1% on VAS used for water jet stimuli in DH demonstrated in Tables 3, 5, and 6. J Clin Dent. 1997;24(11):80813. Soft tissues were isolated with cotton rolls, and adjacent teeth were isolated with cotton pellets. Google Scholar. Colgate Sensitive Pro-Relief Enamel Repair Toothpaste provides clinically proven instant and lasting relief for sensitive teeth For instant relief, apply directly to each sensitive tooth with finger tip and gently massage for 1 minute, up to twice daily DH most commonly involves the facial surfaces of maxillary and mandibular permanent teeth. Gently removes stains and helps restore the natural whiteness of your teeth. The findings have revealed that both statistically and clinically significant change in mean scores of DH was observed with Pro-argin and 8% strontium acetate with p<0.05 relative to baseline for immediate and sustained relief from DH using clinical parameters of SCASS and VAS. Colgate Sensitive Pro-Relief efektywnie i szybko znosi nadwraliwo zbw, zamyka kanaliki zbinowe w ktrych s zakoczenia nerww, dziki czemu blokuje bl. The outcomes are in concordance with the previous studies conducted by Layer and Hughes [26], Zang and Shaw [27], and Mason et al. Colgate Sensitive Pro Relief offers a solution that is clinically proven to relieve sensitivity pain. In each study, a single fingertip application of Colgate Sensitive Pro Relief was found to provide significant immediate relief relative to the comparative toothpaste, a result that was maintained over the subsequent three days with twice-daily brushing with the same toothpaste. The formula consists of Arginine, an amino acid naturally found in saliva and also calcium from calcium carbonate. 2010;23(Spec No A):14A-9A. J Clin Periodontol 42 S17 (2015) 4. For instant relief, apply directly to each sensitive tooth surface and massage for one minute, up to twice a day. With its unique Pro-Argin technology, this sensitive toothpaste will give you instant* relief from sensitivity as it helps to seal and repair the sensitive areas of your teeth**. California Privacy Statement, No side effects, apart from money not well spent. Therefore, in the current study, we used a dental explorer and the air blast and water jet stimuli from the triple syringe of the dental unit for testing DH to control the subjective variations in treatment response. We were using the PAS version.11, two independent sample t-test with 95% confidence interval and 80% power of test, meanSD of air blast stimulus test score of test group 1.860.41 and control group 2.220.41 two weeks after baseline test score, the calculated sample size was 22 [21] which was raised to 35 including five as drop out for each group (Fig. Can be used after the Colgate Sensitive Pro-Relief Desensitizing Paste. Colgate Sensitive Pro-Relief Enamel Repair contains Pro-Argin formula, helping to remineralise enamel, strengthen teeth against acid in food and drinks, plus instantly plugs channels to sensitive nerves. All rights reserved. A meta-analysis by Matranga et al. Our study included an Asian population, and most of the published literature was associated with the Caucasian population. If symptoms persist, talk to your healthcare professional. The statistically significant change in mean scores of DH was observed with FCPS with p<0.05 relative to baseline for sustained relief from DH at follow-ups on day 3, week 2, week 4, and week 6, using clinical parameters of SCASS and VAS. It also strengthens tooth enamel by helping rebuild weak spots. OTC dentifrices with Pro-argin and strontium acetate are effective for immediate pain relief from DH, and FCPS could be the best possible treatment option for long term management of DH. Elsevier; 2015. p. 3344. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. J Clin Exp Dent. The sensitive toothpaste works in different ways to fight cavities, remove plaque, promote gum health and freshen breath. Comparative efficacy of BioMin-F, Colgate Sensitive Pro-relief and Sensodyne Rapid Action in relieving dentin hypersensitivity: a randomized controlled trial. Colgate Sensitive Pro-Relief works by plugging the channels to block tooth sensitivity and with regular use, it builds a long-lasting protective barrier that acts like a seal against sensitivity. The total sample size was 140 participants, with thirty-five in each group. . With its unique Pro-Argin technology, this sensitive toothpaste will give you instant* relief from sensitivity as it helps to seal and repair the sensitive areas of your teeth (with continued use twice a day). Register now and gain access to: 8 hours ECPD Product samples Patient materials Register here * For instant relief, apply directly to the sensitive tooth with finger tip and gently massage for 1 minute. 2016;3(1):0504. Another study by Hines et al. Another study by Hines et al. Helps repair teeth by forming a mineral layer that re-constructs the sensitive part of the tooth, with regular use; Seals the open nerve channels for instant relief, and helps prevent sensitivity from re-occurring; Plus the freshness you trust from Colgate Brush twice daily. p values of<0.05 were considered as statistically significant. For instant relief, apply directly to each sensitive tooth surface and massage for one minute, up to twice a day. Grading of Recommendations, Assessment, Development and Evaluations. The benefits are backed by over a decade of clinical research, summarized as follows. 2017;59(4):4618. It revealed an immediate improvement with strontium acetate more than Pro-argin on SCASS. Dentine hypersensitivity (DH) is a chronic condition with acute, transient pain in non-carious teeth that originates in response to thermal stimuli such as hot or cold, chemicals like acidic or sweet or salt, and mechanical stimuli due to exposure to dentinal tubules without any apparent clinical disease [1]. 2010;21(2):428. SEALS & REPAIRS: Pro-Argin technology helps to seal and repair the sensitive areas of teeth. All rights reserved. [28] reporting the immediate effect of 8% strontium acetate in alleviating clinical symptoms of DH with clinically and statistically significant (<0.001) measures relative to baseline [26]. In addition, they were responding to air-blast stimulus on the Schiff cold air sensitivity scale (SCASS) with scores2 [22]. The participants with self-reported sensitivity in teeth were clinically diagnosed with DH. Holland GR, Narhi MN, Addy M, Gangarosa L, Orchardson R. Guidelines for the design and conduct of clinical trials on dentine hypersensitivity. They reported more clinical efficacy with BioMin than Pro-argin reduction in air-blast stimulated DH on VAS after one month [39]. Colgate Sensitive Pro-Relief Instant Relief works as a shield that blocks pathways to pain instantly. Dentin hypersensitivity (DH) is a sharp toothache that influences a patients' oral health-related quality of life. Colgate Sensitive Pro-Relief Original Toothpaste This toothpaste gives you the freedom to forget about tooth sensitivity. Great Savings & Free Delivery / Collection on many items. Douglas-de-Oliveira DW, Vitor GP, Silveira JO, Martins CC, Costa FO, Cota LOM. The primary analysis population could be described as 32 participants per treatment group after lost to follow-ups of 12 out of 35 enrolled in the six-week trial who responded to the air blast stimulus for the primary outcome measure of treatment response one minute after topical application and after three days and two, four and six weeks subsequently, on SCASS with scores of2. FCPS was incorporated in OTC dentifrice with calcium, low contents of fluoride, and high contents of phosphate ions. For instant relief, just apply directly to the sensitive tooth with finger tip and gently massage for one minute. 2010;11:32. The second null hypothesis was that mean scores for pain due to DH among different treatment groups for sustained relief remains the same, and it was considered to be rejected at a p value0.05. Plus it has the freshness you trust from Colgate! These fluorapatite crystals were less susceptible to acidic dissolution than hydroxyapatite crystals and thus were more desirable [13]. Table 5 presents the change in the mean scores of VAS against mechanical stimulus from baseline to subsequent efficacy interval within each treatment arm. Use regularly to enjoy long-lasting relief from sensitivity*. Table 3 demonstrates the percent change in the mean scores of DH on SCASS relative to baseline within the group for each treatment arm. See patient relevant information on Colgate.com. Another . For more great Dental Care products like toothpaste and mouthwash, continue browsing online and buy in-store at B&M. Colgate Sensitive Instant Relief Toothpaste 75ml Product code: 326795 2.49 Subject to availability - visit your nearest store CONCLUSION: The study results support the following conclusions: (1) Colgate Sensitive Pro-Relief toothpaste provides a significantly more reduction in dentin hypersensitivity than Sensodyne. A head-to-head comparative evaluation of these most effective bioactive agents, such as arginine and BAG-based desensitisers, was suggested by Martins et al. Nachar Sinus Rinse System, 4pcs Professional Baby Nasal Irrigator Portable Infant Nose Cleaner Quick Rinse Device All Natural Relief - BPA Free More Convenient. For lasting relief and gum protection, apply twice daily using a sensitive toothbrush, making sure to brush all surfaces of teeth including sensitive areas. Another meta-analysis by Hu et al. Dentin hypersensitivity. The arginine, calcium carbonate and phosphate plug created by Colgate Sensitive Pro Relief remains intact with ongoing use, even when exposed to acid challenges. 2. The study's primary objective was to investigate pain relief in one minute with Pro-argin and strontium acetate in DH measured on SCASS as a primary outcome measure and VAS as a secondary outcome measure. Comparative evaluation of desensitizing efficacy of dentifrice containing 5% fluoro calcium phosphosilicate versus 5% calcium sodium phosphosilicate: a randomized controlled clinical trial. Hu M-L, Zheng G, Zhang Y-D, Yan X, Li X-C, Lin H. Effect of desensitizing toothpastes on dentine hypersensitivity: a systematic review and meta-analysis. A randomised controlled, triple-blinded, phase-3 clinical trial was conducted at the Department of Periodontology at Dr Ishrat-ul-Ebad Khan Institute of Oral Health Sciences (DIKIOHS) in Dow University of Health Sciences (DUHS), Karachi, Pakistan from September 2019 to December 2020. While FCPS in BioMin F can be the best possible treatment option for long-term management of DH in the form of OTC dentifrices. Lavender SA, Petrou I, Heu R, Stranick MA, Cummins D, Kilpatrick-Liverman L, et al. Clinically proven amino acid formula with Pro-Argin technology to provide sensitivity relief. 1). . Colgate* Sensitive Pro-Relief TM/MC Toothpaste with Pro-Argin TM/MC Technology is the first toothpaste that is clinically proven to provide instant & lasting relief from dentin hypersensitivity. 2008;29(8):1S-35S. However, they also suggested further comparative evaluations of two dentifrices with large sample sizes as limited scientific evidence was found in previous studies [16]. Participants were asked to pick up the envelope from the box. Colgate Sensitive Pro Relief was found to achieve 91% dentin occlusion, compared to 67% for the stannous fluoride toothpaste. YYYY Colgate-Palmolive Company. Significantly greater sensitivity reduction with twice - daily brushing compared to control toothpaste with potassium ions. J Evid Based Dent Pract. who examined FCPS and Pro-argin formulations in 2018. SHOULD A PATIENT CONTINUE USING Colgate SENSITIVE INSTANT Relief Repair & Prevent TOOTHPASTE ONCE THE DENTINE SENSITIVITY HAS GONE? For instant relief, just apply directly to the sensitive tooth with finger tip and gently massage for one minute. J Clin Periodontol 42 (2015), 17, 4. Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. Mahmoodi B, Wood R, Cook R. Protection and acid resistivity of bioactive-glasses, arginine and calcium silicate. Matranga D, Matera F, Pizzo G. Evaluating the statistical methodology of randomized trials on dentin hypersensitivity management. Help Caregivers Understand Caries | Colgate Professional, compared to a leading brand of desensitizing toothpaste, Colgate Sensitive Pro Relief Repair and Prevent, Colgate Sensitive Pro Relief Enamel Repair, Colgate Sensitive Pro Relief Multi Protection. Colgate Sensitive Pro-Relief works by plugging the channels to block tooth sensitivity and with regular use, it builds a long-lasting protective barrier that acts like a seal against sensitivity. Was this answer helpful? Colgate Sensitive Instant Relief Enamel Toothpaste with Pro-Argin technology to help seal and repair the sensitive areas of teeth. Patel VR, Shettar L, Thakur S, Gillam D, Kamala DN. For children 6-12 years of age, once a week or less frequently. OTC dentifrices were applied and massaged gently with the applicator on at least two sensitive teeth per subject at two different sites, including cementoenamel junction and exposed dentinal surface, by the doctor in the office during the first visit. Paired sample T-test was used to compute mean scores to observe change relative to baseline at each time point. Yang ZY, Wang F, Lu K, Li YH, Zhou Z. Arginine-containing desensitizing toothpaste for the treatment of dentin hypersensitivity: a meta-analysis. Clin Cosmet Investig Dent. The secondary analysis population could be described as 20 participants per treatment group out of 35 enrolled in the six-week trial who responded to mechanical and water jet stimuli on VAS with scores of4 as secondary outcome measures. Get the best deals for COLGATE Sensitive Pro Relief Complete Protection Toothpaste 110g. Colgate Sensitive Pro-Relief Complete Protection sensitivity toothpaste is clinically proven for instant and lasting relief from sensitivity pain. Holland G, Narhi M, Addy M, Gangarosa L, Orchardson R. Guidelines for the design and conduct of clinical trials on dentine hypersensitivity. 2018;2018:110. Colgate Sensitive Instant* Relief Enamel Repair tandkrm ger dig kliniskt bevisad lngvarig lindring** mot ilningar i tta veckor nr du anvnder den tv gnger om dagen. [18] in a meta-analysis in 2020. Innehller slipmedel med ltt polerande effekt p flckar samt fluor som minskar risken fr karies. Product Details For instant relief, apply directly to the sensitive tooth with finger tip, and massage gently for 1 minute, once a week or less frequently. Tandkrmen har ett slipmedel som ger en mild polering och tar bort yttre flckar och fluor skyddar tnderna mot karies. Therefore, the first null hypothesis was that mean scores for pain due to DH among different treatment groups for immediate relief remain. Akber A, Ali NS, Shabbir S, Wahid U, Farooqui WA. 0:00 / 0:30 Colgate Sensitive Pro-Relief Challenge Advert April 2012 178,990 views Mar 29, 2012 Take the Colgate Sensitive Pro-Relief Challenge to Show more 15 Dislike Share. The loss of tooth enamel is the most common cause of tooth sensitivity and is not affected by cavities, gum disease, or other problems. For best performance, keep cap closed when not in use. J Dent Probl Solut. Trials. Docimo R et al. Colgate Sensitive Pro-Relief Enamel Rebuild also: Fights cavities Strengthens enamel Freshens breath Vegan . This clinical trial was not funded by any agency in public, commercial or not-for-profit sectors. However, there was no significant treatment difference between dentifrices containing Pro-argin and strontium acetate (p>0.05) at each efficacy interval. Colgate SENSITIVE INSTANT Relief Repair & Prevent Toothpaste delivers instant* and long-lasting sensitivity relief plus gum protection. The prime focus of treatment nowadays is based on the exploration of novel materials to remineralise the exposed tubular endings and mimic and restore the structure of the dentin [11]. For instant relief, just apply directly to the sensitive tooth with fingertip and gently massage for one minute. For patients in the dental chair, it can be used to rapidly ease hypersensitivity pain, facilitate examinations and make dental procedures more comfortable. [33] again reported a 54% clinical reduction in DH with Pro-argin in eight weeks clinical trial using SCASS. J Clin Dent. Compend Contin Educ Dent. (US). Colgate Sensitive Pro Relief Teeth Whitening Sensitivity Toothpaste, 75ml 4.9 out of 5 stars 12 7 offers from SAR 33.95 Colgate Sensitive Pro Relief Base Instant Sensitivity Relief Toothpaste, 75ml 4.3 out of 5 stars 20 5 offers from SAR 31.25 Colgate Total 12 hour Protection Pro - Gum Health Toothpaste 75ml Pro-Argin showed a greater reduction in DH with mean scores of (1.340.68) (4.201.70) (3.052.17) followed by strontium acetate (1.570.81) (4.651.87) (3.751.97) on SCASS and VAS for mechanical and water jet stimuli, one minute after application. More robust trials with a large number of participants are recommended for furtherassessing the impact of DH on the oral health-related quality of life and the difference in the effectiveness of treatments.