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It is made from purified partially depolymerised Alfa cellulose relatively free from both organic and inorganic contaminants. Microcrystalline Cellulose E460 MSDS 1. F. Lerk, G.K. Bolhuis, A.H. De Boer, Effect of Microcrystalline Cellulose on liquid penetration in and disintegration of directly compressed tablets, Journal of Pharmaceutical Sciences, 68 (1979) 205-211. >> };khd5x=fr SUBSTANCE IDENTIFICATION 1.1. PROSOLV SMCC, silicified microcrystalline cellulose, is a unique combination of microcrystalline cellulose (MCC) and colloidal silicon dioxide (CSD).A high functionality and multifunctional excipient, it requires less complex processing, has high inherent functionality, and passes that functionality on to the drug formulation. United Nations Sustainable Development Goals, Alginates Protanal, Manucol, Protacid and More, Barrier membrane, Controlled release hydrophilic matrix, Taste masking, Carrageenan Gelcarin, Viscarin and More, Controlled release hydrophilic matrix, Muco-adhesive, Rheology modifier, Rheology modifier/stabilizer, Thin films, Rheology modifier, Rheology modifier/stabilizer, Binder, Controlled release hydrophilic matrix, Rheology modifier, Rheology modifier/stabilizer, Shell - hard capsule, Tablet coatings, Thin films, Topical, Capsules, Other, Solutions, Suspensions, Tablets, Controlled release hydrophilic matrix, Hot melt extrusion, Muco-adhesive, Osmotic pump, Muco-adhesive, Rheology modifier, Rheology modifier/stabilizer, Thin films, Topical. The application areas for Avicel Microcrystalline cellulose are immense and encompass many industrial sectors such as food, pharmaceuticals, and cosmetics. This extends the funcionality of microcrystalline cellulose to meet specific viscosity, gelling, suspension and stabilizing properties ChemPoint is an approved supplier of LATTICE MCC in industrial applications, providing dedicated marketing, sales, order fulfillment, and technical support for customers in the EMEA region, Protect and improve AI potency, entrap oil droplets and improve stability, physical barrier that helps suspend particles and breaks down under shear and reforms quickly under rest. An internally cross-linked sodium carboxymethyl cellulose (NaCMC), it aids in the disintegration and drug dissolution of pharmaceutical tablets, capsules, and granules. Htn@sHaYoEJ*H[G&o)o9;0s N'3[*%M]vAu#9Tqpg9D& If breathing is difficult or if . Revision No. msdsinfo@fmc.com (Email - General Information) FMC Europe NV Avenue Mounier 83 1200 Brussels, Belgium 353 21 435 4133 (General Information - Cork, Interestingly, the discovery of Avicel was accidental, the team was attempting to break up hydrolysed cellulose using a Waring Blender. X\o^ (Microcrystalline Cellulose) DATE PREPARED: 1/7/2016 Page 1 of 4 Section 1. }[eD-1-8$#Yi^$o8Nc6vwfw;wBT~[Rgi1?%T*/J:/'+Gf'Ae*j@{Rh+2oN|Sbtt;z#v8})F#z=:*]q+U>+ .e ^Q-{@ RPC t/(If>8P&%wNPMJw,VI2aUqRqe3bC,a;C&4RQSf*(=I$r{'%jmk1LUZV(*is6r&wQPAAoID4p?,"lp:wE+)v(_w 'yelVnMh=gIYjK:9v{$G;b8=lGG1_,h^0F2`a~Kusz1p#NS*qt6,F:7+Rma-4u} DINFzJ"Mlctg*~HEge They are made up of sulfated and non-sulfated repeating units of galactose and 3,6-anhydrogalactose. Burger King, McDonald's and other fast food companies list in the ingredients of several of their foods, microcrystalline cellulose (MCC . Powder becomes slippery when wet. 8 0 obj "R}~Q:~pgg'"l/O:OV~ @zo7g;)K;=d'}z8}7w7?Iuw?w~ikK^^'d4k;g_u_LOC6($uiz["Dw#j{ogw~0B"ty'{DqXmImPiww#({LDo^/w;?EW>;b$l/fmQ-1GG/jls}>N\UbZWi,`:O?e;hD8}uC?L{yiD>_2?0 :f =eU}|r=r?P5){{o:tzY- F kNdOaM;p0Nmm7A!Va/eWzgT5vw Ur?0J. PRODUCT AND COMPANY IDENTIFICATION PRODUCT NAME: Avicel PC 611 Microcrystalline Cellulose CHEMICAL FAMILY: Carbohydrate, Cellulose Derivative SYNONYMS: Microcrystalline cellulose (INCI name): MCC, cellulose gel; Sodium Carboxymethylcellulose: NaCMC, CMC, SCMC, Carboxymethylcellulose GENERAL USE: Personal Care MANUFACTURER FMC BioPolymer 1735 Market Street Philadelphia, PA 19103 (800) 526-3649 (General Information) msdsinfo@fmc.com (Email - General Information) FMC Europe NV Avenue Mounier 83 1200 Brussels, Belgium 353 21 435 4133 (General Information - Cork, Ireland) 2. Tel: 1-239-598-5088 sales@espllc.us www.espllc.us. endobj . The charts below provide guidance on how to select and use standard and co-processed grades of Avicel Microcrystalline cellulose in pharmaceutical products. Microcrystalline Cellulose, Colloidal Silicon Dioxide: 50: 0.20 - 0.30: Best in class binder. X]s ;/4'OslUK:|QY`IL|w @ I!*2T~IN?*}y2*49]yOQ*VG%Gu,;&9zE{q==xvrv}rd(yG*qN6E0K$IBWhe (Microcrystalline Cellulose Market Pr. vdZ@Rgl{eU+7N!3!|hUmW)~}U*7k i@j)q["MEydtP"ftFu]t }JN~A"8lz7#}J.i@ qaj/QU<5OrVMfl{pL? on Avicel microcrystalline cellulose, the most trusted excipient brand for decades. METHOCEL products have been in continuous production for more than 70 years with production facilities and deep product expertise located around the globe. F. Steele, M. Tobyn, S. Edge, A. Chen & J. N. Staniforth.Physicochemical and Mechanical Evaluation of a Novel High Density Grade of Silicified Microcrystalline Cellulose, Drug Development and Industrial Pharmacy, 30:1 (2004), 103-109. . No. /Resources 2 0 R We are artists at heart and creators by nature. No. Patel, F. Podczeck, Investigation of the effect of type and source of Microcrystalline Cellulose on capsule filling, International Journal of Pharmaceutics, 128 (1996) 123-127. 1.3. Note that Avicel Microcrystalline cellulose is available in different particle sizes and moisture grades that have different properties and applications. stream GRINDSTED Xanthan Gum is a naturally fermented product of carbohydrates and is applied in various liquid, semi-solid and solid pharmaceutical dosage forms. The chemical structure of cellulose is shown below: In the biosynthesis of cellulose, two molecules of -D-glucose molecules combine via a condensation reaction (elimination of one molecule of water) to form the so-called cellobiose unit. Various Gelcarin and Viscarin carrageenan grades are used by the pharmaceutical industry to achieve specific gelling for controlled drug release, thickening, and stabilizing properties desired in various formulations. Dyvo5bp#bR W7~IF C" d6zLz~!#>@HO}sx;hm>> XiDqLN MD'F2`jI7ZWu,JK%5e9~:R>LAm\WyY0lk=ZNP;pZ23)P0GG~%e[ d8GIXRo&. ( Same quality to grades 102/90M, but very low moisture content (< 1.5 %) for processing water-sensitive actives. Cellulose microcrystalline Revision Date 25-Dec-2021 SARA 313 Not applicable SARA 311/312 Hazard CategoriesSee section 2 for more information CWA (Clean Water Act) Not applicable Clean Air Act Not applicable OSHA - Occupational Safety and Health Administration Not applicable CERCLA Not applicable California Proposition 65 This product contains the following Proposition 65 chemicals. Avicel PC 611 (FMC Biopolymer) . PharmaCentral 2021 . )rFHVNzNaJlIo$5ZH(`8Z>s'$UVVWUyD+[t? $4%&'()*56789:CDEFGHIJSTUVWXYZcdefghijstuvwxyz ? /Type/Page It is a white, free-flowing powder. Meet our leadership team. : 1. <> The highly reactive amorphous regions selectively hydrolyze, releasing the crystallites, which are subsequently mechanically dispersed. JRS Pharma: PROSOLV SMCC 90: Microcrystalline Cellulose, Colloidal Silicon Dioxide: 125: 0.25 - 0.37: Formulas in which a balance of flow and compaction is required. Request media, explore upcoming events and read our latest updates. /Producer(Sub Systems, Inc.)/CreationDate(D:20181207095625+05'00')/ModDate(D:20181207095625+05'00')/Creator(Sub Systems, Inc.) Millipore. Microcrystalline cellulose (MCC) for industrial purposes is usually obtained from wood pulp and purified cotton linters. 1 0 obj Chemical Name Microcrystalline cellulose (INCI Name): MCC, cellulose gel Common Name Avicel PH105 Microcrystalline Cellulose CAS Number 9004-34-6 Impurities and/or Stabilizing Additives No data available Section 4: First Aid Measures General Advice No data available If Inhaled Remove person to fresh air. The table below lists the typical nutritional information of microcrystalline cellulose: Quantitative nutritional analysis of Avicel Microcrystalline cellulose (in 100g)1. Manufacturer: FMC BioPolymer. Manufactured by: China . Avicel is a brand name by Dupont for grades of Microcrystalline cellulose. More sophisticated drug discovery techniques have led to pipeline compounds that require solubility enhancement to be therapeutically effective. endobj The 'Substance identity' section is calculated from substance identification information from all ECHA databases. <> The most. In summary, Avicel microcrystalline cellulose is virtually inert, its energy content is very low or zero and it is not absorbed. MSDS Ref. This unique functionality can be used in a diversity of applications such as controlled release dosage forms, enteric coatings, microencapsulation and stabilization in solutions and suspensions. Microcrystalline cellulose in certain fiber supplements may cause mild side effects ().These may include gas, bloating and increased stool production.. !,K`I[O@U|$+i 8sB|+"B@'2^7[2XKrd#5b % The cellulose molecule is formed through repeated condensation of cellobiose units. Similarly, the European Food Safety Agency has also evaluated Microcrystalline cellulose and established that it is not absorbed systemically and excreted unchanged. EMCOCEL 90 M. 130. However, it yields non-digestible fibre. Material Safety Data Sheet or SDS for Cellulose microcrystalline 102331 from Merck for download or viewing in the browser. AFFINISOL HPMC HME offers hot melt extrusion process flexibility in choosing a polymer viscosity that optimizes drug release profiles and against the factors affecting solubility. FMC, JRS and Mingtai were estimated to hold for . Buy Chemicals. Explore our end markets, products, ingredients and essential solutions or get in touch with us about your order. Molecular weight: Not Applicable 1.5. Product Specifications: Chemical and Physical: Loss on drying, % NMT 6.0* Viscosity, cps, 1.2% solids, 120 sec 39 to 91 . 5 0 obj Ui[(lY[|//o)ZmqbQT-Y.M|se[)m?(WRV.W8J/j}9>X.VNsZNOp'^14nuXM%rea5]@ MKnNe Description: Microcrystalline Cellulose is a term for refined wood pulp manufactured through plant fibre hydrolysis. Avicel PH-200 microcrystalline cellulose NF, Ph. By producing Avicel . << The United States Food and Drug Administration considers microcrystalline cellulose a safe material for all animal species. Avicel PC 611 (FMC Biopolymer) Supplied by. pH 6.0 to 8.0 . To meet their exacting standards, we deliver a wide choice of relevant solutions that are simultaneously replicable, scalable and high performing. It should be noted that native cellulose itself is completely indigestible, and its hydrolysis during the production of microcrystalline cellulose does not alter its behaviour in the intestine. 3t;zAXa[j.7ZX[GL9e,>6sVV`T6`#W Combinations of microcrystalline cellulose (MCC) and sodium carboxymethyl cellulose (Na-CMC) are commonly used as stabilising agents and suspending agents in pharmaceutical formulations. xv}O2' H~KEe9>G/,:9\i . : CL-611NF Date Approved: 01/13/2010. HMo@9, U Q!R/1*;` iq/iVO"5VI}dn.#q^(fJ),BN yb5*4reh1"!E?mR*%fK,e4?A\{OAXr1' tx&Ul{J,57n%PV E2eMS5'UOL wdD{s)4N-m ab K * ~CVHg}{J2.M}O)^}|Z{V+ >AW|? eqgP}OF'v7heLP&Y,eoo`x7lR}0iRVP],=`_2rS'*X$b)+XV2;fbQDgkgx:IZ|v>lDD/TDqz %RL No: 9004-34-6-5 Version: Global Date Approved: 10/16/1998 . For this reason, nutritionists regard standard powdered microcrystalline cellulose as having zero energy content. Avicel Microcrystalline cellulose is composed of insoluble fibre and does not contribute any other material of nutritional importance.